Oncogenic RAS Networks Suppression: Reversibly Ionic Oligonucleotide‐Based Nanoparticles Caged microRNA‐143 Inhibit KRAS‐Mutated Colon Cancer Growth in Tumor‐Bearing Mice (Adv. Therap. 2/2023)

Bone morphogenetic protein signaling and growth suppression in colon cancer.

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily, which utilize BMP receptors and intracellular SMADs to transduce their signals to regulate cell differentiation, proliferation, and apoptosis. Because mutations in BMP receptor type IA (BMPRIA) and SMAD4 are found in the germline of patients with the colon cancer predisposition syndrome juvenile p...

A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells.

BACKGROUND In colon cancer, K-Ras oncogenes, which appear to be linked to chemoresistance and poor prognosis, are activated in more than 50% of cases, whereas the tumor suppressor gene p53 is mutationally altered in about 70% of all cases. The transcription factor p53, which is frequently mutated at codon 273, maintains wild-type configuration and possibly carries out residual functions. Althou...

Blocking oncogenic Ras signaling for cancer therapy.

The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream cytoplasmic or nuclear events. Each mammalian cell contains at least three distinct ras proto-oncogenes encoding closely related, but distinct proteins. Activating mutations in these Ras proteins result in consti...

Antioxidants reversibly inhibit the spontaneous

Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors.

Glutamate Receptors Matthew Volgraf,† Pau Gorostiza,‡,£ Stephanie Szobota,‡,§ Max R. Helix,† Ehud Y. Isacoff,*,‡,# and Dirk Trauner*,†,# Department of Chemistry, UniVersity of California, Berkeley, California 94720, Department of Molecular and Cell Biology, UniVersity of California, Berkeley, California 94720, and Material Science DiVision and Physical Bioscience DiVision, Lawrence Berkeley Nat...